Mixture Design of Experiments

Course Description

This course is specifically designed to meet the analytical needs of those individuals working within FDA regulated industries. Course covers all aspects of mixture design including pre-DOE, simplex lattice, centroid, screening and custom mixture designs. The course requires 8 hours of instruction.


This course is required for all scientists, engineers and quality professionals who actively work on all aspects of discovery, product and process development where the goal is to characterize, optimize and improve product and process performance.


ESDA and DOE are suggested courses prior to MixDOE.

Course Objectives

  1. Apply the principles of robust design to Mixture Experiments.
  2. Design mixture experiments appropriate for the information of interest.
  3. Use and apply the structures of simplex and optimal designs for product and process development and problem solving.
  4. Ensure the mixture design is efficient.
  5. Use regression techniques in order to analyze the results and make process/product improvements.
  6. Use JMP software to design and analyze experiments.

Detailed Course Outline

Section I: Introduction and Two Factor Mixture Designs

Experimental preparation and pre-DOE Two Factor Mixture Designs

Section II: Simplex Lattice Designs

Section III: Simplex Centroid and ABCD Screening Designs

Simplex Centroid ABCD Screening Designs Extreme Vertices Designs

Section IV: Extreme Vertices Designs

Section V: Optimal Designs

Section VI: Custom Design